Cardinals vs. Steelers prediction, odds, spread, injuries, trends for NFL Week 13

A full betting preview for the Pittsburgh Steelers' Week 13 matchup against the Arizona Cardinals.

Nov 26, 2023; Cincinnati, Ohio, USA;  Pittsburgh Steelers running back Najee Harris (22) runs
Nov 26, 2023; Cincinnati, Ohio, USA; Pittsburgh Steelers running back Najee Harris (22) runs / Joseph Maiorana-USA TODAY Sports

The Pittsburgh Steelers will try to win their third straight game at home on Sunday when they play the Arizona Cardinals. The Steelers opened as six-point favorites over the Cardinals, but the number has moved slightly down to 5.5 points.

The Steelers had a tight divisional win over the Bengals last week as the offense finally found a little spark with Matt Canada not calling plays anymore. Meanwhile, the Cardinals dropped their second straight game last week, losing 37-14 to the Rams.

Below, we will break down this NFC West-AFC North Week 13 matchup and give our best bet!

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Cardinals vs. Steelers Odds, Spread and Total

Cardinals vs. Steelers Betting Trends

  • The Cardinals are 2-4 ATS on the road this season
  • The OVER is 4-1 in Arizona’s last five games vs. AFC North opponents
  • Pittsburgh is 4-2 ATS at home this season
  • The UNDER is 8-1 in the Steelers’ last nine games

Cardinals vs. Steelers Injury Reports

Cardinals Injury Report

  • Michael Wilson - WR - Questionable
  • Kevin Strong - DE - Questionable
  • Antonio Hamilton Sr. - CB - Questionable
  • Joey Blount - S - Questionable
  • Starling Thomas V - CB - Questionable

Steelers Injury Report

  • Minkah Fitzpatrick - S - Questionable
  • Montravius Adams - DT - Questionable
  • Calvin Adams III - WR - Questionable

Cardinals vs. Steelers How to Watch

  • Date: Sunday, Dec. 3
  • Game Time: 1 p.m. EST
  • Venue: Acrisure Stadium
  • How to Watch (TV): CBS
  • Cardinals Record: 2-10
  • Steelers Record: 7-4

Cardinals vs. Steelers Key Players to Watch

Arizona Cardinals

Kyler Murray: The veteran quarterback was under constant pressure by the Rams’ defense during last week's 37-14 loss. Murray completed 60% of his passes for 256 yards and scored two touchdowns (one rushing), but was also sacked four times. Murray hasn’t shown any signs of rust since making his regular season debut a few weeks ago. However, he’ll be tested by a Steelers’ defense with two outstanding pass rushers in T.J. Watt and Alex Highsmith.

Pittsburgh Steelers

Najee Harris: The former Alabama running back has had a tough time running the football this season (4.2 YPC). However, Harris was successful on the ground against Cincinnati’s defense last week, which is a good sign heading into this weekend’s game. The 25-year-old had a season-high 99 yards and a touchdown on 15 carries. Before last week’s 99-yard performance, the most yards Harris ran for was 82 against the Browns. If the Steelers want to get into the playoffs, they’ll need the former first-round pick to build off this breakout performance.

Cardinals vs. Steelers Prediction and Pick

After escaping with a two-point home win over the Falcons in Week 10, the Cardinals have lost their last two games against the Texans and Rams. In both losses, Arizona allowed Texans RB Devin Singletary and Rams RB Kyren Williams to rush for 100 yards.

Now the Cardinals will have to go up against Harris and Jaylen Warren, who both can rush for 100 yards. The Steelers’ offense looked much better last week, recording 421 total yards, but only scored 16 points. Pittsburgh has to be better in the red zone (1-for-4 last week vs. CIN), but last week’s showing was a step in the right direction.

The Cardinals have yet to win a game on the road this season, which I don’t see changing this week against the Steelers. However, at the same time, I don’t see Pittsburgh having a 30-point outburst like the Rams did last week.

The Steelers will likely score 20 points, which should be enough as their defense only gives up 18.6 points per game. Therefore, I’ll lean on the UNDER, which has been hitting consistently in Steelers games this season.

Game odds refresh periodically and are subject to change.