Steelers coast into their Bye Week in NFL Week 6 Picks and Predictions

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San Francisco 49ers (5-0) vs Cleveland Browns (2-2), Sunday at 1 P.M. EST

Prediction: 49ers 42, Browns 17

There are a bunch of different injuries currently going on within the Browns organization that could affect the outcome of this game. Cleveland might be without Deshaun Watson, and it seems like Myles Garrett could be dealing with an issue. Even if those two were fully healthy, there are not too many teams that could stop the 49ers right now.

New Orleans Saints (3-2) vs Houston Texans (2-3), Sunday at 1 P.M. EST

Prediction: Saints 25, Texans 23

C.J. Stroud could upset a handful of games this season with the way he is playing. The Saints are running the ball well right now and Houston does not have the best defense to stop that phase of attack. Expect a close game that comes down to the wire. Stroud's non-turnover streak ends here as the Saints talented defense will force an interception late.

Indianapolis Colts (3-2) vs Jacksonville Jaguars (3-2), Sunday at 1 P.M. EST

Prediction: Jaguars 27, Colts 19

A big AFC South matchup here that could not come at a worse time for the Colts after Anthony Richardson suffered an injury last week. Jacksonville is coming off two weeks across the pond and got a big win against the Bills in their last matchup. The Jaguars should be a tough battle for the Colts to overcome and those advantages will get the Jaguars a big divisional win.

Carolina Panthers (0-5) vs Miami Dolphins (4-1), Sunday at 1 P.M. EST

Prediction: Dolphins 41, Panthers 23

The Panthers are in a tough spot right now with almost no positives coming from their team. Miami is on the other foot even though they have struggled to beat playoff contenders throughout last year and early into this season. It should be another curb stomp this week by the Dolphins as they are the superior team at home against a rebuilding Carolina club.