Steelers vs 49ers: Who the experts are taking in this brutal Week 1 matchup

Pittsburgh Steelers v San Francisco 49ers
Pittsburgh Steelers v San Francisco 49ers / Daniel Shirey/GettyImages
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Its finally opening week in the NFL and there should be some interesting matchups to kick off the season. Each year during the first week of competition, there are tons of upsets and unexpected outcomes. The Steelers open their season at home as they host a tough NFC opponent with the San Francisco 49ers.

Nick Bosa might be out of the lineup and George Kittle is battling an injury leading up to the game. Those two being out or limited could play a big factor in the final score of this game. The 49ers are the favorites to win this game right now when you look at the betting odds. The Steelers are starting to get more predictions their way with the possibility of Bosa missing this contest.

CBS Sports has the Steelers making the upset happen in their home opener

CBS Sports prediction: Steelers 26, 49ers 23

We open up this article with a prediction from Pete Prisco of CBS Sports. He is a quality writer for them and someone who frequents this series. He has the Steelers finding a way to swing a field goal in their favor when it is all said and done. There are many things that could work in the 49ers' favor with some of the issues that Pittsburgh carries into this game.

Even though the 49ers are coming off a better season overall, they have a lot of issues of their own. Brock Purdy is back, but he is returning after no practice during the preseason and an elbow injury that knocks a lot of quarterbacks out of the league. Pile that on top of Bosa potentially being out and that leads to this tight game with the Steelers predicted to win.